ABSTRACT
Abstract Objective: The aim of this study was to study the curative effect and the relative mechanism of modified photodynamic therapy combined with Taohong Siwu Decoction in the treatment of hyperplastic scar after severe burn, in order to provide a stable, safe and satisfactory scheme for scar repair. Methods: Forty cases with hyperplastic scars after severe burns admitted to the plastic surgery department from May 2021 to May 2022 were divided into a control group and an observation group by means of the random number table method. The control group was treated with ordinary laser therapy combined with Taohong Siwu Decoction, while the observation group was treated with modified photodynamic therapy combined with Taohong Siwu Decoction. The Vancouver Scar Scale (VSS) was assessed in both groups, and the clinical effectiveness of both groups was compared. HE-staining was performed on the scar tissue of the same patient before and after treatment to observe the changes in the arrangement of fibroblasts. The Vascular Endothelial Growth Factor (VEGF), β-Transforming Growth Factor (TGF-β), and Platelet-Derived Growth Factor (PDGF) in the tissue samples of both groups were detected by quantitative real-time PCR. The patients were followed up for 6 months, and their satisfaction, side effects, and scar recurrence were observed. Results: Compared with the control group, the VSS score in the observation group was lower (p < 0.05). The therapeutic effect of the observation group was superior to the control group after 3 months (p < 0.05). After 3-months of therapy, the arrangement of fibroblasts in the scar became looser in two groups, and the observation group was more looser. The VEGF, TGF-β and PDGF levels in tissue samples of the observation group were lower than those in the control group after 3 months of treatment (p < 0.05). The satisfaction of the observation group was higher than that of the control group (p < 0.05). The adverse reactions between the two groups showed no difference (p > 0.05), while the recurrence rate was lower in the observation group (p < 0.05). Conclusion: Modified photodynamic therapy combined with Taohong Siwu Decoction shows remarkable efficacy in patients with hyperplastic scars after severe burns. It can improve the color, thickness, vascular distribution, and softness of the scar, and reduce the level of cytokines related to tissue repair. At the same time, it can improve patients' satisfaction with the aesthetic appearance and reduce the recurrence rate, providing a new comprehensive therapy that is safer and more effective, simple and quick, and easy to promote in the clinic.
ABSTRACT
ABSTRACT: Biodiversity plays a key role in human welfare by providing agricultural, economic, and health benefits. However, following the industrial revolution, the rapid expansion of the human population and subsequent economic activities have caused a dramatic loss in global biodiversity, resulting in significant disturbances to ecosystems and our own living conditions. Accordingly, the conservation of biodiversity has become one of the most important challenges for humanity. The vast numbers of plants, animals, and microorganisms, the enormous genetic diversity of these species and the different ecosystems to which these organisms belong are all part of a biologically diverse planet. A substantial proportion of the world's biodiversity has been destroyed, this loss is a catastrophe for all living species, including humans. Fortunately, we are working to remedy the destruction of our ecosystems. Herein, we summarized the discovery and development of biodiversity as a field of study and discuss the importance of the genetic and metabolite diversity. We proposed potential solutions to the loss of biodiversity with the aim of facilitating further exploration and identification of biodiversity, contributing for human welfare through the conservation of human habitats.
RESUMO: A biodiversidade desempenha um papel fundamental no bem-estar humano, proporcionando benefícios agrícolas, econômicos e de saúde. No entanto, após a revolução industrial, a rápida expansão da população humana e as subsequentes atividades econômicas provocaram uma perda drástica na biodiversidade global, resultando em perturbações significativas para os ecossistemas e nossas próprias condições de vida. Consequentemente, a conservação da biodiversidade tornou-se um dos desafios mais para a humanidade. O grande número de plantas, animais e microrganismos; a enorme diversidade genética destas espécies; e os diferentes ecossistemas aos quais pertencem esses organismos fazem parte de um planeta biologicamente diversificado. Uma proporção substancial da biodiversidade mundial foi destruída. Essa perda é uma catástrofe para todas as espécies vivas, incluindo os humanos. Felizmente, estamos trabalhando para remediar a destruição de nossos ecossistemas. Neste artigo resumimos a descoberta e o desenvolvimento da biodiversidade como área de estudo e discutimos a importância da análise funcional e metabólica. Propomos soluções potenciais para a perda de biodiversidade com o objetivo de facilitar a exploração e identificação da biodiversidade, contribuindo para o bem-estar da humanidade através da conservação dos habitats da nossa espécie.